Gpm6a ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGpm6a ELISA Kit for Rat(Rattus norvegicus)

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Gpm6a (Gene name),

Neuronal membrane glycoprotein M6-a (Protein name ), GPM6A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gpm6a(m6a);

Protein name:

Neuronal membrane glycoprotein M6-a(M6a);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with OPRM1.

Function:

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell projection Axon Cell projection Dendritic spine Cell projection Filopodium Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons.

Protein Attributes:

Sequence length:

278

Sequence:

50:

100:

150:

200:

250:

278:

YEDIKSKEEQ | ELHDIHSTRS | KERLNAYT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000014312

KEGG:

rno:306439

UniGene:

Rn.34370

Pfam:

PF01275

Uniprot:

Q812E9

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ELISA Kit for Rat M6a

Cat.:

E9379b

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96T

ELISA Kit for Rat M6a

Cat.:

E9379m

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96T

ELISA Kit for Rat M6a

Cat.:

E9379r

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96T

ELISA Kit for Rat M6a

Cat.:

E9379h

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96T

CLIA Kit for Rat M6a

Cat.:

U9379r

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96T

CLIA Kit for Rat M6a

Cat.:

U9379h

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96T

CLIA Kit for Rat M6a

Cat.:

U9379m

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Packing:

96T

CLIA Kit for Rat M6a

Cat.:

U9379b

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96T

Polyclonal Antibody for Rat M6a

Cat.:

P9379Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat M6a

Cat.:

P9379Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat M6a

Cat.:

P9379Rb-m

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40ug/0.2ml

Monoclonal Antibody for Rat M6a

Protein for Rat M6a

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation."
Mukobata S. , Hibino T. , Sugiyama A. , Urano Y. , Inatomi A. , Kanai Y. , Endo H. , Tashiro F.
Biochem. Biophys. Res. Commun.297:722-728(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
4.

"Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis."
Ahmed F. , Torrado M. , Zinovieva R.D. , Senatorov V.V. , Wistow G. , Tomarev S.I.
Invest. Ophthalmol. Vis. Sci.45:3081-3090(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-188 (ISOFORM 2)
5.

"The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation."
Alfonso J. , Fernandez M.E. , Cooper B. , Flugge G. , Frasch A.C.
Proc. Natl. Acad. Sci. U.S.A.102:17196-17201(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
6.

"Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling."
Wu D.F. , Koch T. , Liang Y.J. , Stumm R. , Schulz S. , Schroder H. , Hollt V.
J. Biol. Chem.282:22239-22247(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH OPRM1
7.

"Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a."
Fuchsova B. , Fernandez M.E. , Alfonso J. , Frasch A.C.
J. Biol. Chem.284:32075-32088(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TOPOLOGY;DISULFIDE BOND;MUTAGENESIS OF CYS-162; CYS-174; CYS-192 AND CYS-202
8.

"Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress."
Cooper B. , Fuchs E. , Flugge G.
PLoS ONE4:E3659-E3659(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);TISSUE SPECIFICITY;INDUCTION
9.

"Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation."
Brocco M.A. , Fernandez M.E. , Frasch A.C.
Eur. J. Neurosci.31:195-202(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF THR-10; SER-256; SER-267 AND THR-268
10.

"Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts."
Scorticati C. , Formoso K. , Frasch A.C.
J. Neurochem.119:521-531(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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